Probiotics Regulate Gut Microbiota and Immune Homeostasis to Prevent and Treat Food Allergy : a Review

Authors

• Yao CHEN, School of Health Science and Engineering , University of Shanghai for Science and Technology , Shanghai 200093 , China
• Zumeng XIA, Infinitus (China ) Company Ltd ., Jiangmen 529199 , China
• Yijin YANG, School of Health Science and Engineering , University of Shanghai for Science and Technology , Shanghai 200093 , China
• Lianzhong AI, School of Health Science and Engineering , University of Shanghai for Science and Technology , Shanghai 200093 , China
• Guangqiang WANG, School of Health Science and Engineering , University of Shanghai for Science and Technology , Shanghai 200093 , China
• Yan ZHANG, Angel Yeast Co ., Ltd., Yichang 443003 , China
• Zhen LUO, Infinitus (China ) Company Ltd ., Jiangmen 529199 , China
• Yong ZHOU, Infinitus (China ) Company Ltd ., Jiangmen 529199 , China
• Yongjun XIA, School of Health Science and Engineering , University of Shanghai for Science and Technology , Shanghai 200093 , ChinaFollow

Corresponding Author(s)

夏永军（1981—），男，博士，教授，博士研究生导师，主要从事食品微生物研究。E-mail：dreamup@126.com

Abstract

Food allergy (FA) is a common immunological disorder,and its pathogenesis is primarily associated with a complex regulatory process involving CD 4+ T cells in the immune system,such as the polarization of Th 2 cells and the imbalance between Treg/Th 17 cells.The balance of intestinal immune cells plays a critical role in the development of FA,while dysbiosis of the gut microbiota may disrupt this balance,thereby contributing to the onset of FA.Probiotic intervention targeting the gut microbiota can directly or indirectly influence the functions of immune cells to regulate immune responses,representing a promising approach for the prevention and treatment of FA.The authors discuss the potential of probiotics in modulating gut microbiota,regulating intestinal barrier integrity and T cell balance as a novel strategy for FA therapy.This study aims to deepen the understanding of the complex interactions among FA,immune cells,and gut microbiota,providing theoretical references for future research and clinical applications.

Publication Date

1-15-2026

First Page

13

Last Page

24

DOI

10.12441/spyswjs.20250106001

Recommended Citation

CHEN, Yao; XIA, Zumeng; YANG, Yijin; AI, Lianzhong; WANG, Guangqiang; ZHANG, Yan; LUO, Zhen; ZHOU, Yong; and XIA, Yongjun (2026) "Probiotics Regulate Gut Microbiota and Immune Homeostasis to Prevent and Treat Food Allergy : a Review," Journal of Food Science and Biotechnology: Vol. 45: Iss. 1, Article 2.
DOI: 10.12441/spyswjs.20250106001
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol45/iss1/2

References

［1］ DURHAM S R，SHAMJI M H.Allergen immunotherapy：past，present and future ［J］.Nature Reviews Immunology，2023，23（5）：317-328.
［2］ SICHERER S H，SAMPSON H A.Food allergy：epidemiology，pathogenesis，diagnosis，and treatment ［J］.The Journal of Allergy and Clinical Immunology，2014，133（2）：291-307.
［3］ LAMBRECHT B N，HAMMAD H.The immunology of the allergy epidemic and the hygiene hypothesis ［J］.Nature Immunology，2017，18（10）：1076 -1083.
［4］ BOUSQUET J，PFAAR O，AGACHE I，et al.ARIA -EAACI care pathways for allergen immunotherapy in respiratory allergy ［J］.Clinical and Translational Allergy，2021，11（4）：e12014.
［5］ POUESSEL G，LEZMI G.Oral immunotherapy for food allergy：translation from studies to clinical practice ？ ［J］.The World Allergy Organization Journal，2023，16（2）：100747.
［6］ RUSSELL S L，GOLD M J，HARTMANN M，et al.Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma ［J］.The EMBO Reports，2012，13（5）：440-447.
［7］ FORT M M，CHEUNG J，YEN D，et al.IL-25 induces IL-4，IL-5，and IL- 13 and Th 2-associated pathologies in vivo［J］.Immunity，2001，15（6）：985-995.
［8］ SHI J L，DONG P F，LIU C，et al.Lactobacillus rhamnosus Probio-M 9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism ［J］.Food & Function，2023，14（24）：10784 -10795.
［9］ SHAO H M，MIN F F，HUANG M J，et al.Novel perspective on the regulation of food allergy by probiotic：the potential of its structural components ［J］.Critical Reviews in Food Science and Nutrition，2024，64（1）：172-186.
［10］ SARAVIA J，CHAPMAN N M，CHI H B.Helper T cell differentiation ［J］.Cellular & Molecular Immunology，2019，16（7）：634-643.
［11］ NAKATA J，HIROTA T，UMEMURA H，et al.Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy ［J］.Asia Pacific Allergy，2019，9（2）：e18.
［12］ SHIN H S，SEE H J，JUNG S Y，et al.Turmeric （Curcuma longa） attenuates food allergy symptoms by regulating type 1/type 2 helper T cells （Th1/Th2） balance in a mouse model of food allergy ［J］.Journal of Ethnopharmacology，2015，175：21-29.
［13］ DUCHESNE M，OKOYE I，LACY P.Epithelial cell alarmin cytokines：frontline mediators of the asthma inflammatory response ［J］.Frontiers in Immunology，2022，13：975914.
［14］ SHAMJI M H，SHARIF H，LAYHADI J A，et al.Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma ［J］.Journal of Allergy and Clinical Immunology，2022，149（3）：791-801.
［15］ MAYNARD C L，HARRINGTON L E，JANOWSKI K M，et al.Regulatory T cells expressing interleukin 10 develop from Foxp 3+ and Foxp 3- precursor cells in the absence of interleukin 10［J］.Nature Immunology，2007，8（9）：931-941.
［16］ LLUIS A，DEPNER M，GAUGLER B，et al.Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood ［J］.The Journal of Allergy and Clinical Immunology，2014，133（2）：551-559.
［17］ TORTOLA L，JACOBS A，POHLMEIER L，et al.High-dimensional T helper cell profiling reveals a broad diversity of stably committed effector states and uncovers interlineage relationships ［J］.Immunity，2020，53（3）：597-613.e6.
［18］ PACKI K，MATYSIAK J，KLIMCZAK S，et al.Analysis of the serum profile of cytokines involved in the T-helper cell type 17 immune response pathway in atopic children with food allergy ［J］.International Journal of Environmental Research and Public Health，2022，19（13）：7877.
［19］ HANG S Y，PAIK D，YAO L N，et al.Author correction：bile acid metabolites control TH 17 and Treg cell differentiation ［J］.Nature，2020，579（7798）：E7.
［20］ ZHAO Y Z，LIU Z S，QIN L，et al.Insights into the mechanisms of Th 17 differentiation and the Yin-Yang of Th17 cells in human diseases ［J］.Molecular Immunology，2021，134：109-117.
［21］ DONG P，FENG J jing，YAN D yong，et al.Early-life gut microbiome and cow ’s milk allergy-a prospective case-control 6-month follow-up study ［J］.Saudi Journal of Biological Sciences，2018，25（5）：875-880.
［22］ FRISCHMEYER-GUERRERIO P A，GUERRERIO A L，CHICHESTER K L，et al.Dendritic cell and T cell responses in children with food allergy ［J］.Clinical & Experimental Allergy，2011，41（1）：61-71.
［23］ ZHOU X，YU W，LYU S C，et al.A positive feedback loop reinforces the allergic immune response in human peanut allergy ［J］.Journal of Experimental Medicine，2021，218（7）：e20201793.
［24］ MEULENBROEK L A P M，VAN ESCH B C A M，HOFMAN G A，et al.Oral treatment with β-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow ’s milk allergy ［J］.Pediatric Allergy and Immunology，2013，24（7）：656-664.
［25］ LIU J，CAO X.Regulatory dendritic cells in autoimmunity：a comprehensive review ［J］.Journal of Autoimmunity，2015，63：1-12.
［26］ BUNYAVANICH S，BERIN M C.Food allergy and the microbiome：current understandings and future directions［J］.Journal of Allergy and Clinical Immunology，2019，144（6）：1468 -1477.
［27］ SHARMA G，IM S H.Probiotics as a potential immunomodulating pharmabiotics in allergic diseases：current status and future prospects ［J］.Allergy，Asthma & Immunology Research，2018，10（6）：575.
［28］ ABDEL-GADIR A，STEPHEN-VICTOR E，GERBER G K，et al.Microbiota therapy acts via a regulatory T cell MyD 88/ROR γt pathway to suppress food allergy ［J］.Nature Medicine，2019，25（7）：1164 -1174.
［29］ GU S M，XIE Q，CHEN C，et al.Gut microbial signatures associated with peanut allergy in a BALB/c mouse model ［J］.Foods，2022，11（10）：1395.
［30］ BERNI CANANI R，PAPARO L，NOCERINO R，et al.Gut microbiome as target for innovative strategies against food allergy ［J］.Frontiers in Immunology，2019，10：191.
［31］ AZAD M B，KONYA T，GUTTMAN D S，et al.Infant gut microbiota and food sensitization：associations in the first year of life ［J］.Clinical & Experimental Allergy，2015，45（3）：632-643.
［32］ LEE E，KIM B J，KANG M J，et al.Dynamics of gut microbiota according to the delivery mode in healthy Korean infants ［J］.Allergy，Asthma & Immunology Research，2016，8（5）：471-477.
［33］ JIA L，JIANG Y Y，WU L L，et al.Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th 17/Treg cell balance axis ［J］.Nature Communications，2024，15：1617.
［34］ MA J Y，ZHANG J，LI Q H，et al.Oral administration of a mixture of probiotics protects against food allergy via induction of CD 103+ dendritic cells and modulates the intestinal microbiota ［J］.Journal of Functional Foods，2019，55：65-75.
［35］ BILOTTA A J，CONG Y Z.Gut microbiota metabolite regulation of host defenses at mucosal surfaces：implication in precision medicine ［J］.Precision Clinical Medicine，2019，2（2）：110-119.
［36］ NOVAL RIVAS M，BURTON O T，WISE P，et al.A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis［J］.Journal of Allergy and Clinical Immunology，2013，131（1）：201-212.
［37］ SMITH P M，HOWITT M R，PANIKOV N，et al.The microbial metabolites，short-chain fatty acids，regulate colonic Treg Cell homeostasis ［J］.Science，2013，341（6145）：569-573.
［38］ WALKER W A，IYENGAR R S.Breast milk，microbiota，and intestinal immune homeostasis ［J］.Pediatric Research，2015，77（1）：220-228.
［39］ ZENEWICZ L A.IL-22 binding protein （IL-22BP） in the regulation of IL- 22 biology ［J］.Frontiers in Immunology，2021，12：766586.
［40］ DUHEN T，GEIGER R，JARROSSAY D，et al.Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells ［J］.Nature Immunology，2009，10（8）：857-863.
［41］ ZHANG W D，ZHOU Q，LIU H B，et al.Bacteroides fragilis strain ZY- 312 facilitates colonic mucosa regeneration in colitis via motivating STAT 3 signaling pathway induced by IL- 22 from ILC 3 secretion ［J］.Frontiers in Immunology，2023，14：1156762.
［42］ YANG W J，YU T M，HUANG X S，et al.Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL- 22 production and gut immunity ［J］.Nature Communications，2020，11：4457.
［43］ ZELANTE T，IANNITTI R G，CUNHA C，et al.Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin- 22［J］.Immunity，2013，39（2）：372-385.
［44］ ZHANG Y，LI A L，SUN Y Q，et al.Lactobacillus acidophilus regulates STAT 3 and STAT 5 signaling in bovine β-lg-sensitized mice model ［J］.Dairy Science & Technology，2016，96（4）：501-512.
［45］ TAN J，MCKENZIE C，VUILLERMIN P J，et al.Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways［J］.Cell Reports，2016，15（12）：2809 -2824.
［46］ BEAK J A，PARK M J，KIM S Y，et al.FK506 and Lactobacillus acidophilus ameliorate acute graft-versus-host disease by modulating the T helper 17/regulatory T-cell balance ［J］.Journal of Translational Medicine，2022，20（1）：104.
［47］ HUANG C H，LIN Y C，JAN T R.Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice［J］.Journal of Functional Foods，2017，31：44-51.
［48］ ZHANG J，SU H，LI Q H，et al.Oral administration of Clostridium butyricum CGM CC 0313 -1 inhibits β-lactoglobulin- induced intestinal anaphylaxis in a mouse model of food allergy ［J］.Gut Pathogens，2017，9（1）：11.
［49］ LI N，YU Y，CHEN X H，et al.Bifidobacterium breve M-16V alters the gut microbiota to alleviate OVA-induced food allergy through IL- 33/ST2 signal pathway ［J］.Journal of Cellular Physiology，2020，235（12）：9464 -9473.
［50］ FU W H，CHEN C，XIE Q，et al.Pediococcus acidilactici strain alleviates gluten-induced food allergy and regulates gut microbiota in mice ［J］.Frontiers in Cellular and Infection Microbiology，2022，12：845142.
［51］ HYUNG K E，MOON B S，KIM B，et al.Lactobacillus plantarum isolated from kimchi suppress food allergy by modulating cytokine production and mast cells activation ［J］.Journal of Functional Foods，2017，29：60-68.
［52］ YAHFOUFI N，MALLET J，GRAHAM E，et al.Role of probiotics and prebiotics in immunomodulation ［J］.Current Opinion in Food Science，2018，20：82-91.
［53］ FU L L，SONG J Y，WANG C，et al.Bifidobacterium infantis potentially alleviates shrimp tropomyosin-induced allergy by tolerogenic dendritic cell-dependent induction of regulatory T cells and alterations in gut microbiota ［J］.Frontiers in Immunology，2017，8：1536.
［54］ SUN C M，HALL J A，BLANK R B，et al.Small intestine Lamina propria dendritic cells promote de novo generation of Foxp 3 T reg cells via retinoic acid ［J］.The Journal of Experimental Medicine，2007，204（8）：1775 -1785.
［55］ WU R L，YUAN X F，LI X J，et al.The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization ［J］.Allergy，2022，77（2）：483-498.
［56］ YANG B，LUO Y，LIU Z G，et al.Probiotics SOD inhibited food allergy via downregulation of STAT 6-TIM 4 signaling on DCs ［J］.Molecular Immunology，2018，103：71-77.
［57］ GU S M，YANG D，LIU C L，et al.The role of probiotics in prevention and treatment of food allergy ［J］.Food Science and Human Wellness，2023，12（3）：681-690.
［58］ COX M J，HUANG Y J，FUJIMURA K E，et al.Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome ［J］.PLoS One，2010，5（1）：e8745.
［59］ BERNI CANANI R，SANGWAN N，STEFKA A T，et al.Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants［J］.The ISME Journal，2016，10（3）：742-750.
［60］ DEN BESTEN G，VAN EUNEN K，GROEN A K，et al.The role of short-chain fatty acids in the interplay between diet，gut microbiota，and host energy metabolism ［J］.Journal of Lipid Research，2013，54（9）：2325 -2340.
［61］ GOVERSE G，MOLENAAR R，MACIA L，et al.Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells［J］.Journal of Immunology，2017，198（5）：2172 -2181.
［62］ SONG X Y，ZHANG H H，ZHANG Y B，et al.Gut microbial fatty acid isomerization modulates intraepithelial T cells ［J］.Nature，2023，619（7971）：837-843.
［63］ SONG X Y，SUN X M，OH S F，et al.Microbial bile acid metabolites modulate gut ROR γ+ regulatory T cell homeostasis ［J］.Nature，2020，577（7790）：410-415.
［64］ GONZALEZ-VISIEDO M，KULIS M D，MARKUSIC D M.Manipulating the microbiome to enhance oral tolerance in food allergy ［J］.Cellular Immunology，2022，382：104633.
［65］ CUKROWSKA B，CEREGRA A，MACIORKOWSKA E，et al.The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow ’s milk protein allergy：a multicenter，randomized，double blind，placebo controlled study［J］.Nutrients，2021，13（4）：1169.
［66］ KREFT L，HOFFMANN C，OHNMACHT C.Therapeutic potential of the intestinal microbiota for immunomodulation of food allergies ［J］.Frontiers in Immunology，2020，11：1853.
［67］ SANTOS S S，MIRANDA V C，TRINDADE L M，et al.Bifidobacterium longum subsp.longum 51A attenuates signs of inflammation in a murine model of food allergy［J］.Probiotics and Antimicrobial Proteins，2023，15（1）：63-73.