Modulatory Effects of Flavonoids on IL- 4/IL-13 in Atopic Dermatitis and Their Structure-activity Relationships

Authors

Yueyuan WANG, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;Key Laboratory of Synthetic and Biological Colloids , Ministry of Education , Jiangnan University , Wuxi 214122 , China
Jing LIU, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;Key Laboratory of Synthetic and Biological Colloids , Ministry of Education , Jiangnan University , Wuxi 214122 , China
Chen LI, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;School of Chemistry , Biology and Environment , Yuxi Normal University , Yuxi 653100 , China
Fengfeng CHEN, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;Key Laboratory of Synthetic and Biological Colloids , Ministry of Education , Jiangnan University , Wuxi 214122 , China
Cheng YANG, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;Key Laboratory of Synthetic and Biological Colloids , Ministry of Education , Jiangnan University , Wuxi 214122 , ChinaFollow
Bingtian ZHAO, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China;Key Laboratory of Synthetic and Biological Colloids , Ministry of Education , Jiangnan University , Wuxi 214122 , China

Corresponding Author(s)

杨成（1970—），男，博士，教授，博士研究生导师，主要从事皮肤生理学研究。E-mail：cyang@jiangnan.edu.cn

Abstract

[Objective ] This study aims to explore the ameliorating effects of flavonoids on atopic dermatitis (AD) and their structure-activity relationships.[Method ] Flavonoids were selected through network pharmacology with interleukin- 4 (IL-4) and interleukin- 13 (IL-13) as key targets.The immunoglobulin E (IgE)-induced RBL- 2H3 cell model was employed to evaluate the effects of flavonoids on inflammatory factors,degranulation activities,and calcium ion influx,and the structure-activity relationships were analyzed.Finally,molecular docking was utilized to assist in exploring the action mechanism.[Result ] All of the six flavonoids (luteolin,apigenin,chrysin,quercetin,kaempferol,and fisetin ) screened by network pharmacology had significant inhibitory effects on the expression of IL- 4,IL- 13,tumor necrosis factor- α (TNF- α),cell degranulation,and calcium ion influx.Among them,flavonoids with a hydroxyl group at the C- 5 position and without hydroxyl groups at the C- 3 and C- 3’ positions (apigenin and chrysin ) exhibited the strongest inhibitory activities.Flavonoids without a hydroxyl group at the C- 3 position of the C ring (luteolin,apigenin,and chrysin ) had relatively strong binding energy with signal pathways such as PLC γ,Lyn,and ERK.[Conclusion ] This study provided new ideas for the development of dietary therapies for preventing and ameliorating AD.

Publication Date

7-15-2025

First Page

51

Last Page

63

DOI

10.12441/spyswjs.20241231001

Recommended Citation

WANG, Yueyuan; LIU, Jing; LI, Chen; CHEN, Fengfeng; YANG, Cheng; and ZHAO, Bingtian (2025) "Modulatory Effects of Flavonoids on IL- 4/IL-13 in Atopic Dermatitis and Their Structure-activity Relationships," Journal of Food Science and Biotechnology: Vol. 44: Iss. 7, Article 6.
DOI: 10.12441/spyswjs.20241231001
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol44/iss7/6

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