Research Progress in Biological Activities , Mechanisms of Action , and Applications of Antimicrobial Peptides

Authors

Yuxin JIAO, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China
Ruolan SHAN, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China
Xufeng WANG, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China
Maolong CHEN, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China
Li WEN, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China
Yunhui CHENG, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China;School of Food Science and Engineering , Qilu University of Technology , Jinan 250353 , China
Hao WU, School of Food and Bioengineering , Changsha University of Science and Technology , Changsha 410114 , China;State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , ChinaFollow

Corresponding Author(s)

吴昊（1990—），男，博士，副教授，硕士研究生导师，主要从事食品生物技术及食品酶工程研究。E-mail：haowu@csust.edu.cn

Abstract

The widespread abuse of traditional antibiotics has led to the emergence and development of antimicrobial peptides due to the resultant bacterial resistance.Antimicrobial peptides demonstrate high efficacy in combating infectious pathogens and possess unique antimicrobial mechanisms and biocompatibility,effectively reducing the bacterial resistance rate.The high structural adaptability endows antimicrobial peptides with multiple biological activities,enabling targeted action against diverse types of pathogens and abnormal cells.Accordingly,antimicrobial peptides exhibit a promising development prospect.Enhanced stability contributes to prolonging the in vivo half-life and improving the bioavailability of antimicrobial peptides,which holds crucial importance for improving the clinical translation value of antimicrobial peptides.The author summarizes the research progress in antimicrobial peptides regarding the biological activities,mechanisms of action,and applications in food,agriculture,and medical fields.Furthermore,the author discusses the low stability of antimicrobial peptides in applications and the approaches to enhance their stability and makes an outlook on future research directions and application prospects for antimicrobial peptides.

Publication Date

6-15-2025

First Page

19

Last Page

29

DOI

10.12441/spyswjs.20250324002

Recommended Citation

JIAO, Yuxin; SHAN, Ruolan; WANG, Xufeng; CHEN, Maolong; WEN, Li; CHENG, Yunhui; and WU, Hao (2025) "Research Progress in Biological Activities , Mechanisms of Action , and Applications of Antimicrobial Peptides," Journal of Food Science and Biotechnology: Vol. 44: Iss. 6, Article 21.
DOI: 10.12441/spyswjs.20250324002
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol44/iss6/21

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