Evaluation of the Clinical Alleviation Effect of Bacillus coagulans CCFM 1041 on Functional Constipation

Authors

Huahao CAI, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China;School of Food Science and Technology , Jiangnan University , Wuxi 214122 , China
Linlin WANG, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China;School of Food Science and Technology , Jiangnan University , Wuxi 214122 , China
Qingwei YAO, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China
Xudan SHEN, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China
Xingxing CHEN, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China
Shumao CUI, Wuxi Institute for Specialized Nutrition and Health , Wuxi 214029 , China;School of Food Science and Technology , Jiangnan University , Wuxi 214122 , ChinaFollow

Corresponding Author(s)

崔树茂（1986—），男，博士，研究员，博士研究生导师，主要从事食品生物技术研究。E-mail：cuishumao@jiangnan.edu.cn

Abstract

[Objective ] Functional constipation is a chronic gastrointestinal disorder caused by multiple factors,with a relatively high and increasing prevalence in China.Previous studies have found that Bacillus coagulans (B.coagulans )CCFM 1041 can alleviate symptoms of functional constipation in mice.[Method ] A double-blind,randomized controlled clinical trial was conducted to evaluate the clinical efficacy of CCFM 1041 in relieving functional constipation.A total of 73 participants were observed for changes in constipation-related indicators,serum levels of gastrointestinal regulatory neurotransmitters,and gut microbiota before and after the intervention.[Result ] After taking CCFM 1041,84.2% of participants experienced increased bowel movement frequency,and 94.7% of participants showed improved stool consistency.Compared with the control group,CCFM 1041 significantly raised the mass concentrations of motilin (MTL ) and gastrin (GAS ) in the serum and effectively regulated the gut microbiota.The correlation analysis indicates that CCFM 1041 may exert the effect by modulating gut microbiota.[Conclusion ] CCFM 1041 can effectively alleviate symptoms of functional constipation in participants.The research results provide scientific evidence for the application of B.coagulans CCFM 1041 in constipation relief and offer support for screening probiotics effective in alleviating constipation.

Publication Date

5-15-2025

First Page

41

Last Page

49

DOI

10.12441/spyswjs.20250224001

Recommended Citation

CAI, Huahao; WANG, Linlin; YAO, Qingwei; SHEN, Xudan; CHEN, Xingxing; and CUI, Shumao (2025) "Evaluation of the Clinical Alleviation Effect of Bacillus coagulans CCFM 1041 on Functional Constipation," Journal of Food Science and Biotechnology: Vol. 44: Iss. 5, Article 5.
DOI: 10.12441/spyswjs.20250224001
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol44/iss5/5

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