In Vitro Probiotic Effects of Dextran with a Small Molecular Weight

Authors

Dingkun ZHANG, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Lei WANG, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Ziling YI, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Beibei WEI, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Deming RAO, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Zhiyong GUO, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Sheng CHEN, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , China
Jing WU, State Key Laboratory of Food Science and Resources , Jiangnan University , Wuxi 214122 , China;School of Biotechnology , Jiangnan University , Wuxi 214122 , ChinaFollow

Corresponding Author(s)

吴敬（1969—），女，博士，教授，博士研究生导师，主要从事酶工程与发酵工程研究。E-mail：jingwu@jiangnan.edu.cn

Abstract

[Objective ] The aim of this study is to explore the effects of dextran with a small molecular weight (SDex ) on the viability of intestinal microorganisms.[Method ] The probiotic effects of laboratory-designed SDex containing only α-1,6 glycosidic bonds was evaluated by in vitro fermentation with nine typical intestinal strains,including strains from the genera Bifidobacterium and Lactobacillus,as well as species such as Escherichia coli and Enterococcus faecalis.The microbial proliferation and organic acid production during fermentation were compared among SDex,commercial dextran 20 (Dex 20),and isomalto-oligosaccharides (IMOs ).[Result ] SDex and IMOs significantly promoted the proliferation of probiotics such as Bifidobacterium and Lactobacillus as well as the production of organic acids,while Dex 20 showed little effects.SDex did not promote the growth of the conditionally pathogenic bacterium Escherichia coli but showed a less positive effect on the neutral bacterium Enterococcus faecalis than IMOs.Neither SDex nor IMOs significantly affected the lactic acid production.However,SDex promoted acetic acid production while SDex enhanced formic acid production by probiotics.[Conclusion ] SDex demonstrates selective probiotic effects of promoting the proliferation of Bifidobacterium and Lactobacillus while exerting little effect on Escherichia coli,which indicates SDex is essential for replenishing existing prebiotics.

Publication Date

5-15-2025

First Page

22

Last Page

30

DOI

10.12441/spyswjs.20230302005

Recommended Citation

ZHANG, Dingkun; WANG, Lei; YI, Ziling; WEI, Beibei; RAO, Deming; GUO, Zhiyong; CHEN, Sheng; and WU, Jing (2025) "In Vitro Probiotic Effects of Dextran with a Small Molecular Weight," Journal of Food Science and Biotechnology: Vol. 44: Iss. 5, Article 3.
DOI: 10.12441/spyswjs.20230302005
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol44/iss5/3

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