Journal of Food Science and Biotechnology
Abstract
[Objective ] This study aims to investigate the ameliorative effects of a Lilium brownii -Plantago asiatica L.compound solid beverage on hyperuricemia and to elucidate its potential mechanisms.[Method ] Network pharmacology was employed to screen the active constituents,potential targets,and related pathways.Key targets were identified based on a protein-protein interaction (PPI) network.Molecular docking was conducted between the key proteins and active constituents.An animal experiment was performed to validate the effects of the compound solid beverage on serum uric acid levels,renal function indices,activities of uric acid-producing enzymes,and the levels of renal urate transporters.[Result ] Network pharmacology analysis indicated that Lilium brownii and Plantago asiatica L.contain a total of 9 active constituents and had 61 common targets with hyperuricemia,among which 13 targets were closely related to the treatment of hyperuricemia,mainly involving the NF- κB and PI3K-Akt signaling pathways.Molecular docking between the top 4 connectivity degree-ranked target proteins identified from the protein-protein interaction network and the 9 active constituents showed binding energy below -5.0 kJ/mol,indicating favorable interactions and suggesting uric acid-lowering potential.The animal experiment showed that compared with the model group,the Lilium brownii -Plantago asiatica L.compound solid beverage reduced the serum uric acid concentration by 30.46% and lowered serum creatinine and blood urea nitrogen levels (P<0.05).In addition,the beverage also decreased renal xanthine oxidase (XOD ) and adenosine deaminase (ADA ) enzyme activities,downregulated the urate transporter 1 (URAT 1) level,and upregulated organic anion transporter 1 (OAT 1) and ATP-binding cassette sub-family G member 2 (ABCG 2) levels in the renal tissue.[Conclusion ] The Lilium brownii -Plantago asiatica L.compound solid beverage may lower uric acid levels and improve renal function-related indices through a multi-constituent,multi-target,and multi-pathway synergistic mechanism.The findings provide a theoretical basis for the development of uric acid-lowering functional beverages.
Publication Date
12-15-2025
First Page
82
Last Page
94
DOI
10.12441/spyswjs.20240930001
Recommended Citation
LI, Feng; HUANG, Jiawei; GUO, Xiaowen; JIANG, Lulu; ZHAO, Hongyan; LI, Qiang; SUN, Chenxiang; FENG, Shuying; and WANG, Qianqian
(2025)
"Therapeutic Mechanisms of a Lilium brownii -Plantago asiatica L.Compound Solid Beverage Against Hyperuricemia,"
Journal of Food Science and Biotechnology: Vol. 44:
Iss.
12, Article 9.
DOI: 10.12441/spyswjs.20240930001
Available at:
https://spsw.spyswjs.cnjournals.com/journal/vol44/iss12/9
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