Effects and Mechanisms of Phytosterol-oil Bodies Emulsion on Lipid Metabolism of Caenorhabditis elegans

Authors

Jie SUN, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , China
Mengyuan YUAN, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , China
Yifei LIU, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , China
Fuyao ZHANG, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , China
Zhuofan YANG, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , China
Guoyou YIN, School of Life Sciences and Engineering , Henan University of Urban Construction , Pingdingshan 467036 , ChinaFollow

Corresponding Author(s)

尹国友（1976—），男，博士，副教授，硕士研究生导师，主要从事生物化学与分子生物学研究。E-mail：30110605@huuc.edu.cn

Abstract

[Objective ] This study aims to explore the lipid-lowering effects of the phytosterol-oil bodies emulsion (POE ).[Method ] Caenorhabditis elegans was taken as a model to evaluate the effects of POE on lipid metabolism,physiological indexes,and expression of genes associated with oxidative stress and fat metabolism.[Result ] Compared with the control group,different mass concentrations of POE reduced the mass fraction of fat (P<0.01) and the relative content of triglycerides (P<0.05),without toxicity to the growth and development of C.elegans (P<0.01).At the same time,it significantly reduced the level of reactive oxygen species and increased the levels of antioxidant enzymes.In addition,POE affected the expression levels of genes related to fat metabolism.qPCR results showed that POE up-regulated the mRNA level of sbp-1,while down-regulating the mRNA levels of fat-2,nhr-80,and fat-5 (P<0.05).[Conclusion ] POE may improve lipid metabolism by slowing fat deposition,regulating the fat peroxidation pathway,and alleviating oxidative stress in C.elegans.

Publication Date

11-15-2025

First Page

143

Last Page

149

DOI

10.12441/spyswjs.20240617005

Recommended Citation

SUN, Jie; YUAN, Mengyuan; LIU, Yifei; ZHANG, Fuyao; YANG, Zhuofan; and YIN, Guoyou (2025) "Effects and Mechanisms of Phytosterol-oil Bodies Emulsion on Lipid Metabolism of Caenorhabditis elegans," Journal of Food Science and Biotechnology: Vol. 44: Iss. 11, Article 15.
DOI: 10.12441/spyswjs.20240617005
Available at: https://spsw.spyswjs.cnjournals.com/journal/vol44/iss11/15

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