Journal of Food Science and Biotechnology
Abstract
[Objective ] This study aims to develop a lipase-mediated furfural oxidation system in ionic liquid for the green synthesis of furoic acid,5-hydroxymethyl- 2-furancarboxylic acid,and 2,5-furandicarboxylic acid under mild reaction conditions.[Method ] Using furfural as the substrate,Novozym 435 lipase as the catalyst,hydrogen peroxide as the oxidant,and 1-butyl- 3-methylimidazolium acetate ionic liquid as the solvent,the conditions including reaction temperature,reaction time,initial furfural concentration,and initial hydrogen peroxide concentration were optimized.The system was further extended to the oxidation of 5-hydroxymethylfurfural,and coupled with a chemical oxidation process using an imidazolium-based ionic liquid and tert-butyl hydroperoxide to achieve one-pot synthesis of 2,5-furandicarboxylic acid.[Result ] Under the optimized conditions,the yield of furoic acid exceeded 99%.The oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl- 2-furancarboxylic acid achieved yield of 94%.2,5-furandicarboxylic acid was synthesized via the one-pot coupled reaction with a yield of 90%.[Conclusion ] This study provides a novel strategy and methodology for the green synthesis of bio-based chemicals such as furoic acid and 2,5-furandicarboxylic acid.
Publication Date
8-15-2025
First Page
61
Last Page
68
DOI
10.12441/spyswjs.20241030001
Recommended Citation
ZHU, Rui; WANG, Yaxin; and ZHANG, Liang
(2025)
"Lipase-mediated Oxidation of Furfural to Furoic Acid,"
Journal of Food Science and Biotechnology: Vol. 44:
Iss.
8, Article 7.
DOI: 10.12441/spyswjs.20241030001
Available at:
https://spsw.spyswjs.cnjournals.com/journal/vol44/iss8/7
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